MyHealthTabs.com | A Trending Content Hub

Gastrointestinal Stromal Tumor (GIST) – What you should know

Gastrointestinal Stromal Tumor (GIST) occurs when the body abnormally grows cells in the gastrointestinal linings. These abnormally growing cells have the potential to develop into cancer and must therefore be treated as early as possible. This type of growth can be observed anywhere along the digestive tract, but it is most commonly observed in the stomach and small intestine.

Causes of GIST

The abnormal growth of cells associated with GIST is typically observed in special cells in the body known as interstitial cells of Cajal (ICCs). These cells are responsible for regulating the involuntary movements that occur in the gastrointestinal tract. According to certain studies, it is assumed that this abnormality in cells is induced as a result of abnormalities or certain mutations found in the DNA. Such mutations result in the improper behavior of the enzyme tyrosine kinase (KIT).

Signs and symptoms of GIST

In most cases, this condition goes undiagnosed for a long period of time, as the symptoms aren’t obvious. In certain cases, when the condition progresses, the following symptoms may be observed:

Abdominal pain and discomfort
Small bumps felt through the skin of the abdomen
Nausea and vomiting
Fatigue
Loss of appetite and feeling full quickly
Bowel obstruction

Treatment options for GIST

Once the condition is diagnosed, the doctors will recommend several treatment options based on its severity. Here are some common treatment options for GIST:

Surgery

Surgery is one of the most common and conventional approaches to tackling tumors and has been practiced for a long time in the cancer industry. However, if the cancerous cells are widespread and highly powerful, a single surgery would be ineffective in many cases and cannot be relied on as a stand-alone treatment option.

Chemotherapy and radiation
For larger and more aggressive tumors, doctors may suggest chemotherapy or radiation therapy to destroy cancer cells and prevent these cells from growing back. This type of therapy is known as adjuvant therapy. Just like surgery, adjuvant therapy has not shown any promising results in patients with GIST either.
Targeted therapy
Since conventional methods of treatment have been rather ineffective in treating GIST, doctors have been trying to come up with newer solutions that work better. Several targeted drugs have been curated to target certain genes in these cancer cells and to inhibit the growth and spread of these cells. Certain medications like imatinib, sunitinib, and regorafenib act as tyrosine kinase inhibitors (TKIs) that prevent the formation of KIT from these cells.

Popular Reads

You Will Not Believe This Common Condition Is One of the Brain Tumor Symptoms

You know about headaches and seizures, but did you know that this common condition is one of the brain tumor symptoms you ought to watch out for? Brain tumors manifest in symptoms for a couple of reasons. First and foremost, the brain is a very compact organ, and there is little to no space to accommodate the growth of other tissue inside the brain. Secondly, depending on exactly where they are growing inside the brain, these tumors push against and impose pressure on certain parts, and cause varying symptoms. Perhaps, the most common early warning symptom of brain tumors is a headache . Headaches may be severe to start off with, or may have a tendency to worsen early in the morning or after any activity. The second most commonly reported symptom of brain tumors is seizures or fits. Also known as convulsion, motor seizures are characterized by sudden involuntary movements of the muscles in a person’s body. Depending on the area that the tumor is pushing against, you may experience different types of seizures. The most common ones are myoclonic and tonic-clonic or Grand Mal seizures. Less common brain tumor symptoms include changes in sensory perceptions without being unconscious, personality/memory changes, nausea and vomiting and fatigue .

Everything You Need to Know About Haemophilia in Children

Get all your questions pertaining to haemophilia in children answered here. A first aid kit is your best friend as a parent. Children seem to know just how to walk in an unbalanced gait and topple over without any external help. The result is an extraordinary number of bumps and bruises that need more than a mother’s kiss to make better. While bruises and scrapes are a normal part of childhood, haemophilia children need extra care. A bruise or cut would heal and scab over for others, but for haemophilia children, even the smallest cuts are a cause of concern. If you are a parent with haemophilia children or would just like to know more about the condition to help your loved ones handle it better, here are the answer to the most common questions when it comes to haemophilia in children. What is Haemophilia? When you get a cut, there are clotting agents in your blood that act quickly to curb the bleeding. However, for haemophilia children, the disease actively stops blood from clotting properly. The result is an excessive loss of blood, which can be very dangerous to the health of haemophilia children. This genetic disorder tends to affect more boys than girls.

Do You Suffer from These Bladder Control Problems in Women?

Do not just live with urinary incontinence – learn what causes it so you can improve bladder control problems in women. If you think that urinary incontinence is a problem that only older women and men deal with, think again. Bladder control problems in women are common, and they affect women of all age groups. Sometimes, there is a clear starting point for bladder control problems in women. You may have just delivered a baby, and are getting back to your active lifestyle, when you suffer through an “accident”. Owing to how embarrassing bladder control problems in women can be, a lot of women never seek help for this treatable condition. Regardless of age, many across the globe are living with bladder control problems in women, and shrouding the condition in secrecy. However, the truth is that more than 13 million people in the United States have incontinence issues. Bladder control problems in women are twice as likely as men. According to the Agency of Healthcare Research and Quality, 30 percent of young women suffer incontinence. The rates of bladder control problems in women increase with age, with 40 percent of middle-aged women, and 50 percent of older women suffering from urinary incontinence.